Liverpool forward Sadio Mane may be out for up to six weeks after suffering a hamstring injury during international duty with Senegal.

Liverpool said in a statement on Tuesday that Mane was substituted just before the end of Senegal's 2-0 World Cup qualifying win over the Cape Verde Islands on Saturday.

"It has now been confirmed that he picked up an injury during that fixture that could keep him out of action for up to six weeks."

The 25-year-old’s absence is a huge blow for manager Jurgen Klopp after the player scored three goals in four Premier League appearances this season.

The injury is especially badly timed for Klopp with Liverpool's bitter rivals Manchester United visiting Anfield on Saturday.

With seven points behind Man United, Liverpool can’t afford to lose more points especially at home.

In his stead, Brazil playmaker Philippe Coutinho will need to work extra hard to hold of United free scoring attack line.

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