A report of a study by some American researchers has found how fat tissues feed tumour that could become cancerous to the body.

They reported on Monday in the journal Cancer Cell that the molecular mechanisms by which fat cells communicate with tumour tissue provide energy to the tumour.

Obesity has been identified as the second leading preventable cause of cancer, and the Sanford Prebys Medical Discovery Institute (SBP) researchers elaborated how the metabolism affects tumour formation.

They found that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice.

The p62 deficiency triggers a shutdown of energy-consuming processes in fat tissue, thereby increasing the availability of nutrients for cancer cells, according to the researchers.


“This work could lead to better therapies that consider cancer not just as a genetic or cellular disease, but as a whole-body process where tumours communicate with metabolic organs to maintain their unlimited appetite for nutrients,” said co-senior author Maria Diaz-Meco, a professor in the Cancer Metabolism and Signaling Networks Programme at the SBP.

“This is a vulnerability that can be targeted therapeutically,” said Diaz-Meco.

Diaz-Meco’s team used a mouse model lacking p62 in fat cells, which leads to increased adiposity and metabolic problems.

They found that p62 deficiency in fat cells promotes the progression and metastasis of prostate cancer in mice by inhibiting a protein complex called mTORC1.

The tumours suppress energy-consuming activities such as fat cell development, a metabolic process called oxidative phosphorylation, and fatty acid metabolism in white fat tissue.

What To Do To KEep Weight In Check

As a result, more fatty acids and other nutrients are available to support tumour growth.

“This metabolic reprogramming orchestrated by the loss of p62 in adipocytes appears to help tumours cope with the high-energy demands of an aggressive cancer,” said Diaz-Meco.

Additional experiments have shown that p62 deficiency in fat tissue promotes the synthesis of proteins called osteopontin and Cpt1a, which are critical for prostate cancer proliferation, migration and invasion.

These findings are clinically relevant because high levels of osteopontin and Cpt1a are associated with aggressive, metastatic castration-resistant prostate cancer in humans.

“The significance is huge because we identify a new set of therapeutic targets that, if modulated, should block the ability of activated adipose tissue to promote tumour malignancy,” said the paper’s co-auther Jorge Moscat at the SBP.

Losing weight is a tough task, but these two keys things can help you keep your weight in check.

1. Have a healthy and balance diet - fruit and vegetables, starchy carbohydrate, dairy and protein.

2. Be more physically active - find every opportunity to exercise. 

Small manageable changes are helpful for not only losing weight but keeping the weight off. 

If you love soft drinks, this may not be friendly but it is important that you do it to stay healthy.

You just have to cut down on sugary drinks, reduce portion sizes and maintaining regular meal times. 

Also Read: See What WHO Says Is Making Your Child Obese

Always keep an eye on the weight of your children because obese children are more likely to grow into obese adults and obese adults are more at risk of cancer.